H2N2V1, France, Analysis, bibRecord, 000321

Protein-mediated hydroxyl radical generation — The primary event in NADH oxidation and oxygen reduction by the granule rich fraction of human resting leukocytes

Identifieur interne : 000321 ( France/Analysis ); précédent : 000320; suivant : 000322

Protein-mediated hydroxyl radical generation — The primary event in NADH oxidation and oxygen reduction by the granule rich fraction of human resting leukocytes

Auteurs : Martine Torres [France] ; Christian Auclair [France] ; Jacques Hakim [France]

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1979.

RBID : ISTEX:C6EF34B4FA28C4A2F9A51477198C35601FDCE001

English descriptors

KwdEn :
- GRF, H2O2, HO•, O2•, PB, PMN.
Teeft :
- Assay medium, Benzoate, Biophysical research communications, Bovine serum albumin, Catalase, Chem, Febs letts, Ferricytochrome, Ferrocytochrome, Hydroxyl radicals, Incubation medium, Incubation time, Nadh, Nadh oxidation, Nadh oxidation nadh oxidation, Nmol, Scavenger.

Abstract

Abstract: The granule rich-fraction isolated from human resting polymorphonuclear leukocytes is capable of CN-insensitive NADH oxidation and O2-uptake, accompanied by production of superoxide anion, hydroxyl radicals and H2O2. We showed that H2O2 initiates and maintains NADH oxidation and O2-uptake but is also necessary for the formation of superoxide anion and hydroxyl radicals. It acts as a primary substrate for CN-insensitive protein-mediated formation of hydroxyl radicals, which in turn produce superoxide anions, probably through univalent oxidation of NADH as an intermediary.

Url:

https://api.istex.fr/ark:/67375/6H6-NWVGCRQS-G/fulltext.pdf

DOI: 10.1016/0006-291X(79)91508-0

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000E10
to stream Istex, to step Curation: 000E10
to stream Istex, to step Checkpoint: 001534
to stream Main, to step Merge: 002A86
to stream Main, to step Curation: 002935
to stream Main, to step Exploration: 002935
to stream France, to step Extraction: 000321

Links to Exploration step

ISTEX:C6EF34B4FA28C4A2F9A51477198C35601FDCE001

Le document en format XML

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<author><name sortKey="Hakim, Jacques" sort="Hakim, Jacques" uniqKey="Hakim J" first="Jacques" last="Hakim">Jacques Hakim</name>
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<keywords scheme="Teeft" xml:lang="en"><term>Assay medium</term>
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<term>Bovine serum albumin</term>
<term>Catalase</term>
<term>Chem</term>
<term>Febs letts</term>
<term>Ferricytochrome</term>
<term>Ferrocytochrome</term>
<term>Hydroxyl radicals</term>
<term>Incubation medium</term>
<term>Incubation time</term>
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<front><div type="abstract" xml:lang="en">Abstract: The granule rich-fraction isolated from human resting polymorphonuclear leukocytes is capable of CN-insensitive NADH oxidation and O2-uptake, accompanied by production of superoxide anion, hydroxyl radicals and H2O2. We showed that H2O2 initiates and maintains NADH oxidation and O2-uptake but is also necessary for the formation of superoxide anion and hydroxyl radicals. It acts as a primary substrate for CN-insensitive protein-mediated formation of hydroxyl radicals, which in turn produce superoxide anions, probably through univalent oxidation of NADH as an intermediary.</div>
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<name sortKey="Hakim, Jacques" sort="Hakim, Jacques" uniqKey="Hakim J" first="Jacques" last="Hakim">Jacques Hakim</name>
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Protein-mediated hydroxyl radical generation — The primary event in NADH oxidation and oxygen reduction by the granule rich fraction of human resting leukocytes

Protein-mediated hydroxyl radical generation — The primary event in NADH oxidation and oxygen reduction by the granule rich fraction of human resting leukocytes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri